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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a374de659bd3020a1be9425727fc9d0ae45dfd285ed1ed78814b8ae82e2c8bea' 
  AND token = 'jE+5BGWGDcsu8Qs2vF8aGxrcp8FPCQGd/XDPiWF4REs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}