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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00b16d2157b50510c6c49e3ade9208dd6dcc78a3d7f3c0eb32ba40044718df21' 
  AND token = 'oV5fg0o0BLlCCJYO9k4zqyD1R/7xLEjMTOMuwG9YT6k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}