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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2a0003fa0c9f6bbfb2e337a707fe352831d5e996d5c6896037366c9bd08d5db' 
  AND token = 'zOoD2JCVUkI+bT9sVcPccDQtodz6y8UmAA7KOHKoXNg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}