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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5225b85e74a902cef36ad049bc442a219f046f40cad4b010ba891ec10ca4244b' 
  AND token = 'tzyHcf+iddnTByen5Fia3IsdQDnroK9m1wO/pPB0RDw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}