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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e449c62aadc019ec0c2d08b514d80855056b3fb06a909d13d2da1b66551e2b9d' 
  AND token = 'dmb2eqtYZ6u+2/nerUl3tPEuph5LV2WIpaDzbmA+uUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}