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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '444bc59041dd0a3a2fc37e08f20d718cca53ab41dce0f6c700e2da069b83b68c' 
  AND token = '4f8O4Cd3HVxrkXLA8FH16PKzVTFkCSlVoW2bOBmf4pA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}