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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222025f6cd45b8cfbf88971feeeea6356f6ad0a471076a3becabec6302da41dd' 
  AND token = '7ixvYVAYWn6AwNqrO3al8CVTskyIT9tfqLeDAiCNpQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}