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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '501da2203c40ce2bd614b8d82ba0012fe734d6804666eea73c0e3b05665bd19f' 
  AND token = '3z8fo0V7EVd5NEn/qMhU5KnqJSrTEfjBFiQ/CEcm2Bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}