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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '442a0cd2fefd057e3139d4ed1f66365da6dafb8ab03d018794a8c2d44a10d60f' 
  AND token = '8uOS4m1MWdsHiA7gOwmr5uzrHPfy9R7vSVFfN0lapqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}