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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e43cba1dc2a0ade0d5966d379b489b420aedd7f3fe3f74f9afed98f7ae50fbf' 
  AND token = 'UHtL/eyimKlyOOBahW4zJmsf9f5Ck5+3XO6G2u7nTbc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}