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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2172ef8f0b155d45a1f58464bdb98bcdfd481d5405f55d44f4e12d4769fd1015' 
  AND token = 'KmgxddRbDdV5Qch6NN3dTAxcbLqGdd4RL10eTheBacU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}