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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '61befc7ac3a0d0ac68b531510c13dd1bcf6e0cc5a8696f47f1e86f6b60548149' 
  AND token = 'UsXPMlehe+LR8rpNIdUVt4YTDk4oa4YQfCmRhssNZpM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}