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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15a8987d05fa3b112228ffeab1804646b1ff0a7dfcafb64f61f7395d397a492b' 
  AND token = 'UV0olzbTz+EgnqW4lVCu6xT0kdazJMqC3yTyA2w8Vp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}