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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5488e8100664109f97c83689e5bf81b7f06bfec9c5cb2177caf15fc5f2231d0c' 
  AND token = 'JiCo9QdopBuFgNWlKiOO3res6xXqLlNdAdy69BYsSro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}