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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543ffc1320a6a641b7d6f02b8f04e1cc987ad1274ee055baaa477caec8395a06' 
  AND token = 'vEG278GramHKHmMD8jEv7dO/kX+VMV0RSST5/pPvt6A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}