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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41172de3f8a27f2a1192439b0ceb10a9f9e2ac90f4000650f352ddb5cebe68d2' 
  AND token = 'asGWn6NbAlzKjbg3IhMrYYxcqz+EJVtfH+RO3Krx6AE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}