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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c86d0253deebc9ae25b8234bf38a2b269f58bc9f71b2ab4ae23b98d9d89a294' 
  AND token = 'tI7RCY+iPKdb2kJo/EHH9VfWmwWsqKpfIh71D42Nqpk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}