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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de287e1860c77b308a5f58c7aa484bca5e189ce1340504f11a1b48758272a21f' 
  AND token = '0PEW8GUW2xVQctN8hQ9IhmglV2n3MtMBhjPdbnXAF2Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}