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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '059209ca001f3709f04f4d9dacf6ad65a0441692223089d9b5cfa1f2235ab228' 
  AND token = 'g2XBPp5Sv3xKFsoCH/dcEOehhdlRPGTlk9rQmrtbfAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}