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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4bda5697a7c18c579c585c5da2111450b4cbf9e615132cfe5d8b158bf1f160b' 
  AND token = '8Px4R+9Iwivl38xmC2O+EX/AaFRWW4GQVwKTlqUIHPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}