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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e7a057569377cc3be9c10ff7da07c0a68f6f62a65824ed1f816158f6111ca3' 
  AND token = 'RVWpG0kGedfomVpaItcXDmTwkoEiwVwwtUTYHzDnqPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}