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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15af6100d3b09cf931fc08aa092b035254d5f8c395939347e19be4acf23ca499' 
  AND token = 'uPInX4vEFaxm5pSObCskGCqq4kTxH5/KVOqMceptClM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}