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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721ff1aef9ec4306fdb844de66ffcd04e332606e5536c7d14bbd98566267abcf' 
  AND token = 'b+7n2GEnAsrt1y3ZVrPq9Sz1MhUV8DjdUAh0u6w0K0M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}