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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e00ae603f1e6df3e5c759f5afd0d645543987b0f3d71ec651b3a4f54ee9f1178' 
  AND token = 'uGDOYOlSdSHaF34Z+Heu0XcSPKwY9aj8RRra91pcVUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}