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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a601f4d7a203e0a6e202fa0eb641d6e7c9a223b4f83772923bc1200d409bab1f' 
  AND token = 'EmUmu7gswpGP+HusY8b5TZdaegZcLT5ktpor6Knl3yM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}