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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '496e196e6ef3c269ea9d7ab05be43e06a3156a12fb6c8f9ffbeab333ad719689' 
  AND token = '1No1nC1rQPH3yIsOAkEiDo4r9e5OscI2jfcyciZKyFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}