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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '644a0cf39d373b75a1f2f523c385288379123a1372ad674d2df5df2226501b74' 
  AND token = 'DbDsl2ds+pAyk08vmVAGzPrUVQT1PiSiGfco6LuLUtA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}