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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af4a21072e67055b5ec0da676a573e48400f651a41a8e9a7f8da8641455b1349' 
  AND token = 'DyK5zo4RhP66lIoW/I8PRJbBFo4ALFFup+/Azvg3A4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}