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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16620354f90d4952fac07f8c5be0282a9d224602dcde7ede17fb97533b9bf32c' 
  AND token = '+hGZ67hJxYfSiQ0erNSOmdVwAMiFw+8b1XXDFWFIxak=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}