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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66f0b3165bffdb2243d26c7a1c527c4e207a4a853374863903a52d755c85d611' 
  AND token = 'V3vU/wADkMXPhimzIbbTl1hHPhktJheDhhr8ECGrvGE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}