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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e49dabed6b1da3c7423269542fe2e66154cbe41c8edb40ca8e0211b94e1b664' 
  AND token = 'CX9t97xedlLpSAiydRO7GP+VgCoLs6R3l0Pzg0RmmsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}