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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1219fd0746f9888a009d21af20b66b72e6b6754f56ede5dd2d16c41b8568dab' 
  AND token = 'euFA8gODS7JVb1TP1aDVc8uQgMsMWQGZXQ75wBzPUpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}