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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2475fa780c2f2eaf23407a94577d8f111ee6c0b3f48913b19d6d9d816ee1afe2' 
  AND token = 'Qu0Nprf2P/+nOPWJU+AZD+xijijZQDL1ExXblv87mSQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}