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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc78ed3fb491ea4ab61c2094877c98cb8dab41ab1aae746f0b4039f744f39616' 
  AND token = 'A7xmBuYbexR64kCSWbscV7gPyeGYCEZEb4p9GV75/gQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}