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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1278e7c01d381e7cb9d710d38c7a018238d6242945ddcb21311f7f75a9a82969' 
  AND token = 'AUB+BsSNg7hOc6iEHALy9pfmPUvLqd7G+v3bkeV4Gfw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}