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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c2356b95e41cb075db18b8eba1e07e8934ffeab01cf2e1ee1077efde1dfaf46' 
  AND token = 'ZHNIWOg/R0CuI5h9BjGCIwOU5NxY0JHTf9WTXNG8eMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}