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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5159502c12cfa32b49c5af1971cf58446a70922d0c5a51634e76e5322d1bb5ef' 
  AND token = 'j7KNVxc3+NHk/X/jMDcyPMaulfVT0Fe7CBj2Y+Ekil8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}