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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46e6b0cbe29692a7eca0328f0aa18774a8972bb44ccfadb04ad3793922d64a52' 
  AND token = 'ulIDYfHphSHGO5SiMzrOlDaPDoRenA6NXlqg9UU2Zfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}