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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c81cd67a169e5b508cdc43c5da09e0b59aa06491a049f8eb123d334fa130f0a8' 
  AND token = 'zFXkEAjxL/lLBaXF7O3RBKnlhSmtghXDqL/IrolkbO8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}