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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3443874a570975ed292295d33147d78f80bf69a65c780aa1c0cebb9078b830b4' 
  AND token = 'M5UgQ5GN2b/Vym3sTTQ8G4v/leUdbRUvZwgl2rsH1L4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}