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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e859cfe65a479107179a87599f7a7cf4a04658701ce106ab0d43e440d2b235bf' 
  AND token = 'Nrfq36I20Cnos21wlh/GpyF6YYdXxx3Mx5S7Sx1Hg6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}