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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d1ae0005fa9a1f5719a99bb31372cf3d3e62a6581fbe93f5959d44fb66f13f' 
  AND token = 'VlVc5KYiKB3LWCOUmkQqBeYfSB1gub8swZiVBRSMcSY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}