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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '249e2ac231516a9227822a9416ef6e7bb520c345e24172e9f10cb35bd8e65f06' 
  AND token = 'pyyys+4/j6deAfvdRxkZkgeIzHbRJbG/h6nO32iFOZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}