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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '20e1e17417dcf306b8213d602bff5f31cf6fc573cb609a639812b922a86b2206' 
  AND token = 'IOG4NDH07+2RyYrRKqmX9EVPKFkF0h1k0QooXernU9w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}