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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ffa22e195e2dc0b7acdbd0835df8cebad261243d2317ab16c02bb8396ca5cb66' 
  AND token = 'cpoXAZfdrwTzhI1QeQoi9nvp/2xWgDkvnGH+PFKHsGw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}