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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f956533a67f6605840bcc2a6668e27d1f49ade77c94aa91b22f95f9bf5aa89' 
  AND token = '1VVvR0bpaHI5PmmrOLs5UfvaDbyRZC40w+BgZ5j0Ar4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}