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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '751dc78f38c129e5d7da4ebc7e6399f4466e9d2436cf08421348a9c01fdcc790' 
  AND token = 'dV1rktCg4Iz6UrImVqPMXUE+PQivIqq0xUJaS2yvpmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}