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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f15754ff3289278e4512a21a31e9b05b85fc3a96408e06b84b229548390a400' 
  AND token = '+yr3ozp5c5o3cYut6FNwa/9c1ZePlbE8AteA60iy7ic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}