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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d1729ee561f2b966d30c02b9a1b9c5313d0c58a8f05df3fdac2206b2900a066' 
  AND token = 'GNd5zaAw7F1BWbN59C+8dkp+HT9wQ3BogqlRPhhjoSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}