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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4488a298aceadb0f976ae4ce552ae2fcc42689cefa46f24f8487ae774e300c90' 
  AND token = '/z1nFQ6VzJiQoTCpin3xF4QR2UcJ4WOMVDexSn+awVY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}